Metabolic Adaptations to Interrupted Glycosaminoglycan Recycling

Metabolic adaptations to interrupted glycosaminoglycan recycling.

Lysosomal storage diseases (LSD) are metabolic disorders characterized by accumulation of undegraded material. The mucopolysaccharidoses (MPS) are LSDs defined by the storage of glycosaminoglycans. Previously, we hypothesized that cells affected with LSD have increased energy expenditure for biosynthesis because of deficiencies of raw materials sequestered within the lysosome. Thus, LSDs can be...

Metabolic adaptations to arsenic-induced oxidative stress in Isatis cappadocica. Naser Karimi* and Zahra Souri

Arsenic is considered as one of the most important environmental contaminant elements. Some plant species can grow in arsenic contaminated soils and they are able to reduce arsenic toxicity. In this study, a hydroponic experiment was conducted on Isatis cappadocica, a newly-discovered As hyperaccumulator. Accordingly, we conducted this experiment to compare the interaction of effect of arsenic ...

Metabolic Adaptations to Six-month Caloric Restriction

Metabolic Adaptations in Higher Animals

There is a marked increase in the liver glucose 6-phosphatase activity’ of rats fed a diet devoid of a direct source of glucose (1). Also the ingestion of a glucose-free diet containing a high level of protein or fructose causes an increase in liver fructose 1,6-diphosphatase activity in rabbits (2). I f these findings are not special cases, but are representative of a general phenomenon, infor...

Metabolic Adaptations in Higher Animals

Ingestion of a diet containing 40 per cent or more of sucrose causes a rapid rise in liver glucose-6-phosphatase activity1 in the rat (1). The high enzyme activity, which has been interpreted as an adaptive response, is maintained for several weeks at least, if the rat is kept on a diet high in sucrose (2). The glucase-6-phosphatase adaptation is thought to be a result of enzyme synthesis rathe...